This significant book conveys Dr. William E. Pauls enduring enthusiasm for the field of immunology, the incredible accomplishments of the past half-century, and the futures untapped promises.The immune system has incredible power to protect us from the ravages of infection by killing disease-causing microbes or eliminating them from the body. Boosted by vaccines, it can protect us individually and as a 'herd' from diseases such as measles. As Dr. Paul explains, however, the power of the immune system is a double-edged sword: an overactive immune system can wreak havoc, destroying normal tissue and causing diseases such as type I diabetes, rheumatoid arthritis, and multiple sclerosis. The consequences of an impaired immune system, on the other hand, are all too evident in the clinical agonies of AIDS and other immunodeficiency diseases.Packed with illustrations, stories from Dr. Pauls distinguished career, and compelling narratives of scientific discovery,Immunity presents the three laws of the human immune systemuniversality, tolerance, and appropriatenessand explains how the system protects and harms us. From the tale of how smallpox was overcome to the lessons of the Ebola epidemic to the utility of vaccines and the hope that the immune system can be used to treat or prevent cancer, Dr. Paul argues that we must position ourselves to take advantage of cutting-edge technologies and promising new tools in immunological research, including big data and the microbiome.
Preface Part One 1. Defense and Danger 2. Tracing an Immune Response 3. The Laws of Immunology 4. Growing Up and Learning Immunology Part Two 5. Vaccines and Serum Therapy 6. How Is Specificity Achieved? 7. Immunology's ""Eureka"" 8. How Does Each Lymphocyte Develop a Distinct Receptor? 9. B Cells and T Cells Recognize Different Types of Antigens 10. My Foray into the Specificity Problem 11. Genes and Immune Responses 12. The Laboratory of Immunology and the T-Cell Receptor Part Three 13. What Is Tolerance? 14. How Does Tolerance Develop? 15. Regulatory T Cells and the Prevention of Autoimmunity Part Four 16. Different Structures, Different Functions 17. Specific Types of Infections, Specific Types of T-Cell Responses 18. Our Discovery of IL-4 and the Cells That Make It 19. CD8 T Cells 20. Dendritic Cells Part Five 21. An ""Ancient"" Immune Response Controls"" Modern"" Immunity 22. The Microbiome and Innate Immunity 23. Evolution of the Immune System and Innate Lymphoid Cells Part Six 24. The HIV Epidemic and the Office of AIDS Research 25. How the Immune System Causes Rheumatoid Arthritis and Lupus 26. Allergy and Asthma 27. Interleukin-4 and Allergy 28. Can the Immune System Control Cancer? 29. New Parts for Old 30. Julien Conclusion Epilogue Acknowledgments Notes Index
""It is well written, informative and gives detailed descriptions even down to defining platelets'sometimes we make the assumption that individuals know these details but the author has pre-empted this and provided ample explanations, which in essence will widen his audience... I would recommend this book to students, healthcare assistants, clinicians, and nurse specialists working within all areas.""
