As one of the first oncogenes identified, Myc has enjoyed an illustrious history. In reflection of 30 years of research and in excess of 20,000 published articles, two major themes emerge. First, the fine-tuned regulation and numerous activities of Myc in normal cells are unparalleled and a beauty to behold. Second, when this regulation is lost, Myc rears its beastly head and takes the role of one of the most prominent and intriguing of oncoproteins. (From Myc: The Beauty and the Beast by Amanda R. Wasylishen and Linda Z. Penn in Genes & Cancer Vol 1 No 6, 2010.) MYC-A Far-Reaching Cancer Gene edited by Dr. Chi Van Dang at Johns Hopkins is a truly outstanding compilation of comprehensive reviews ("Monographs") that addresses the myriad roles of this very important oncogene in growth, development, metabolism, and cancer. As Dr. Dang states in his introductory remarks, "This special issue captures the excitement that is associated with MYC-mediated tumorigenesis through reviews that span a timeline of MYC research including a fundamental understanding of how the MYC gene itself is regulated, the study of Myc in model organisms, Myc function, and target genes to translational research in search of new therapeutic modalities for the treatment of cancer."
Enigmatic MYC Conducts an Unfolding Systems Biology Symphony - Chi V. Dang Myc: The Beauty and the Beast - Amanda R. Wasylishen and Linda Z. Penn Myc Function in Drosophila - Paola Bellosta and Peter Gallant "You Don't Muck with MYC" - David Levens Chromosome 8q24-Associated Cancers and MYC - Chiara Grisanzio and Matthew L. Freedman Emerging Concepts in the Analysis of Transcriptional Targets of the MYC Oncoprotein: Are the Targets Targetable? - Steven B. McMahon Myc: Maestro of MicroRNAs - Thi V. Bui and Joshua T. Mendell Myc Regulation of mRNA Cap Methylation - Victoria H. Cowling and Michael D. Cole Transcriptional Repression: The Dark Side of Myc - Barbara Herkert and Martin Eilers Myc, Mondo, and Metabolism - Elizabeth J. Sloan and Donald E. Ayer MYC Inactivation Elicits Oncogene Addiction through Both Tumor Cell-Intrinsic and Host-Dependent Mechanisms - Dean W. Felsher Myc Roles in Hematopoiesis and Leukemia - M. Dolores Delgado and Javier Leon Myc and Prostate Cancer - Cheryl M. Koh, Charles J. Bieberich, Chi V. Dang, William G. Nelson, Srinivasan Yegnasubramanian, and Angelo M. De Marzo MYC and Breast Cancer - Jinhua Xu, Yinghua Chen, and Olufunmilayo I. Olopade Targeting MYC Expression through G-Quadruplexes - Tracy A. Brooks and Laurence H. Hurley Therapeutic Targeting of Myc - Edward V. Prochownik and Peter K. Vogt Targeting MYC-Regulated miRNAs to Combat Cancer - Anna Frenzel, Jakob Loven, and Marie Arsenian Henriksson Genes & Cancer Manuscript Submission Guidelines and Information
